منابع مشابه
Natural Products and Synthetic Biology
While the phrasing of this tripartite classification was not intended to describe the current state of natural products research, it could have been, as it provides an apt description of the field today. The organic molecules lumped under the term natural products elude an easy definition. They are a structurally diverse collection of molecules produced by organisms in an idiosyncratic fashion,...
متن کاملSynthetic biology of fungal natural products
Synthetic biology is an ever-expanding field in science, also encompassing the research area of fungal natural product (NP) discovery and production. Until now, different aspects of synthetic biology have been covered in fungal NP studies from the manipulation of different regulatory elements and heterologous expression of biosynthetic pathways to the engineering of different multidomain biosyn...
متن کاملEthical Debates on Synthetic Biology
Background: As an emerging interdisciplinary area of science with a multitude of potential facilities and applications, synthetic biology integrates different disciplines with one another ranging from basic science to engineering. This interdisciplinary branch therefore encompasses sciences that require specific development and ethical approaches. Materials and Methods: Science management princ...
متن کاملIntroduction to the Special Issue “Bioinformatic tools and approaches for Synthetic Biology of natural products”
Microorganisms are the major source for the identification of novel bioactive natural products, which may serve as future lead molecules for drug development to treat infectious and other diseases. However, the research efforts to find suchmolecules have been hampered by high re-discovery rates of known biomolecules and a lack of new innovative screening technologies resulting in reduced screen...
متن کاملBioinformatics for the synthetic biology of natural products: integrating across the Design–Build–Test cycle
Covering: 2000 to 2016Progress in synthetic biology is enabled by powerful bioinformatics tools allowing the integration of the design, build and test stages of the biological engineering cycle. In this review we illustrate how this integration can be achieved, with a particular focus on natural products discovery and production. Bioinformatics tools for the DESIGN and BUILD stages include tool...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2016
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a023994